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Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study

BACKGROUND: Arsenic exposure in drinking water disproportionately affects small communities in some U.S. regions, including American Indian communities. In U.S. adults with no seafood intake, median total urine arsenic is 3.4 μg/L. OBJECTIVE: We evaluated arsenic exposure and excretion patterns usin...

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Autores principales: Navas-Acien, Ana, Umans, Jason G., Howard, Barbara V., Goessler, Walter, Francesconi, Kevin A., Crainiceanu, Ciprian M., Silbergeld, Ellen K., Guallar, Eliseo
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737021/
https://www.ncbi.nlm.nih.gov/pubmed/19750109
http://dx.doi.org/10.1289/ehp.0800509
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author Navas-Acien, Ana
Umans, Jason G.
Howard, Barbara V.
Goessler, Walter
Francesconi, Kevin A.
Crainiceanu, Ciprian M.
Silbergeld, Ellen K.
Guallar, Eliseo
author_facet Navas-Acien, Ana
Umans, Jason G.
Howard, Barbara V.
Goessler, Walter
Francesconi, Kevin A.
Crainiceanu, Ciprian M.
Silbergeld, Ellen K.
Guallar, Eliseo
author_sort Navas-Acien, Ana
collection PubMed
description BACKGROUND: Arsenic exposure in drinking water disproportionately affects small communities in some U.S. regions, including American Indian communities. In U.S. adults with no seafood intake, median total urine arsenic is 3.4 μg/L. OBJECTIVE: We evaluated arsenic exposure and excretion patterns using urine samples collected over 10 years in a random sample of American Indians from Arizona, Oklahoma, and North and South Dakota who participated in a cohort study from 1989 to 1999. METHODS: We measured total urine arsenic and arsenic species [inorganic arsenic (arsenite and arsenate), methylarsonate (MA), dimethylarsinate (DMA), and arsenobetaine] concentrations in 60 participants (three urine samples each, for a total of 180 urine samples) using inductively coupled plasma/mass spectrometry (ICPMS) and high-performance liquid chromatography/ICPMS, respectively. RESULTS: Median (10th, 90th percentiles) urine concentration for the sum of inorganic arsenic, MA, and DMA at baseline was 7.2 (3.1, 16.9) μg/g creatinine; the median was higher in Arizona (12.5 μg/g), intermediate in the Dakotas (9.1 μg/g), and lower in Oklahoma (4.4 μg/g). The mean percentage distribution of arsenic species over the sum of inorganic and methylated species was 10.6% for inorganic arsenic, 18.4% for MA, and 70.9% for DMA. The intraclass correlation coefficient for three repeated arsenic measurements over a 10-year period was 0.80 for the sum of inorganic and methylated species and 0.64, 0.80, and 0.77 for percent inorganic arsenic, percent MA, and percent DMA, respectively. CONCLUSIONS: This study found low to moderate inorganic arsenic exposure and confirmed long-term constancy in arsenic exposure and urine excretion patterns in American Indians from three U.S. regions over a 10-year period. Our findings support the feasibility of analyzing arsenic species in large population-based studies with stored urine samples.
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spelling pubmed-27370212009-09-11 Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study Navas-Acien, Ana Umans, Jason G. Howard, Barbara V. Goessler, Walter Francesconi, Kevin A. Crainiceanu, Ciprian M. Silbergeld, Ellen K. Guallar, Eliseo Environ Health Perspect Research BACKGROUND: Arsenic exposure in drinking water disproportionately affects small communities in some U.S. regions, including American Indian communities. In U.S. adults with no seafood intake, median total urine arsenic is 3.4 μg/L. OBJECTIVE: We evaluated arsenic exposure and excretion patterns using urine samples collected over 10 years in a random sample of American Indians from Arizona, Oklahoma, and North and South Dakota who participated in a cohort study from 1989 to 1999. METHODS: We measured total urine arsenic and arsenic species [inorganic arsenic (arsenite and arsenate), methylarsonate (MA), dimethylarsinate (DMA), and arsenobetaine] concentrations in 60 participants (three urine samples each, for a total of 180 urine samples) using inductively coupled plasma/mass spectrometry (ICPMS) and high-performance liquid chromatography/ICPMS, respectively. RESULTS: Median (10th, 90th percentiles) urine concentration for the sum of inorganic arsenic, MA, and DMA at baseline was 7.2 (3.1, 16.9) μg/g creatinine; the median was higher in Arizona (12.5 μg/g), intermediate in the Dakotas (9.1 μg/g), and lower in Oklahoma (4.4 μg/g). The mean percentage distribution of arsenic species over the sum of inorganic and methylated species was 10.6% for inorganic arsenic, 18.4% for MA, and 70.9% for DMA. The intraclass correlation coefficient for three repeated arsenic measurements over a 10-year period was 0.80 for the sum of inorganic and methylated species and 0.64, 0.80, and 0.77 for percent inorganic arsenic, percent MA, and percent DMA, respectively. CONCLUSIONS: This study found low to moderate inorganic arsenic exposure and confirmed long-term constancy in arsenic exposure and urine excretion patterns in American Indians from three U.S. regions over a 10-year period. Our findings support the feasibility of analyzing arsenic species in large population-based studies with stored urine samples. National Institute of Environmental Health Sciences 2009-09 2009-05-07 /pmc/articles/PMC2737021/ /pubmed/19750109 http://dx.doi.org/10.1289/ehp.0800509 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Navas-Acien, Ana
Umans, Jason G.
Howard, Barbara V.
Goessler, Walter
Francesconi, Kevin A.
Crainiceanu, Ciprian M.
Silbergeld, Ellen K.
Guallar, Eliseo
Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title_full Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title_fullStr Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title_full_unstemmed Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title_short Urine Arsenic Concentrations and Species Excretion Patterns in American Indian Communities Over a 10-year Period: The Strong Heart Study
title_sort urine arsenic concentrations and species excretion patterns in american indian communities over a 10-year period: the strong heart study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737021/
https://www.ncbi.nlm.nih.gov/pubmed/19750109
http://dx.doi.org/10.1289/ehp.0800509
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