A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

Beta-amyloid (Aβ) is thought to be a key contributor to the pathogenesis of Alzheimer disease (AD) in the general population and in adults with Down syndrome (DS). Different assembly states of Aβ have been identified that may be neurotoxic. Aβ oligomers can assemble into soluble prefibrillar oligome...

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Detalles Bibliográficos
Autores principales: Sarsoza, Floyd, Saing, Tommy, Kayed, Rakez, Dahlin, Robert, Dick, Malcolm, Broadwater-Hollifield, Camille, Mobley, Scott, Lott, Ira, Doran, Eric, Gillen, Daniel, Anderson-Bergman, Clifford, Cribbs, David H., Glabe, Charles, Head, Elizabeth
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737113/
https://www.ncbi.nlm.nih.gov/pubmed/19360426
http://dx.doi.org/10.1007/s00401-009-0530-3

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