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Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery
PURPOSE: Glial-derived neurotrophic factor (GDNF) is a potential therapy for stroke, Parkinson’s disease, or drug addiction. However, GDNF does not cross the blood-brain barrier (BBB). GDNF is re-engineered as a fusion protein with a chimeric monoclonal antibody (MAb) to the human insulin receptor (...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Springer US
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737114/ https://www.ncbi.nlm.nih.gov/pubmed/19609743 http://dx.doi.org/10.1007/s11095-009-9939-6 |