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Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke

Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic str...

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Autores principales: Sheikh, Nasrin, Tavilani, Heidar, Rezaie, Aliakbar, Vaisi-raygani, Asad, Salimi, Saeedeh
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737135/
https://www.ncbi.nlm.nih.gov/pubmed/19746169
http://dx.doi.org/10.1155/2009/841468
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author Sheikh, Nasrin
Tavilani, Heidar
Rezaie, Aliakbar
Vaisi-raygani, Asad
Salimi, Saeedeh
author_facet Sheikh, Nasrin
Tavilani, Heidar
Rezaie, Aliakbar
Vaisi-raygani, Asad
Salimi, Saeedeh
author_sort Sheikh, Nasrin
collection PubMed
description Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P < .05, P < .001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r = −0.54, P = .029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity.
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spelling pubmed-27371352009-09-09 Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke Sheikh, Nasrin Tavilani, Heidar Rezaie, Aliakbar Vaisi-raygani, Asad Salimi, Saeedeh J Biomed Biotechnol Research Article Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P < .05, P < .001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r = −0.54, P = .029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity. Hindawi Publishing Corporation 2009 2009-09-02 /pmc/articles/PMC2737135/ /pubmed/19746169 http://dx.doi.org/10.1155/2009/841468 Text en Copyright © 2009 Nasrin Sheikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sheikh, Nasrin
Tavilani, Heidar
Rezaie, Aliakbar
Vaisi-raygani, Asad
Salimi, Saeedeh
Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title_full Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title_fullStr Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title_full_unstemmed Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title_short Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
title_sort relationship between estradiol and antioxidant enzymes activity of ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737135/
https://www.ncbi.nlm.nih.gov/pubmed/19746169
http://dx.doi.org/10.1155/2009/841468
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