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Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke
Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic str...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737135/ https://www.ncbi.nlm.nih.gov/pubmed/19746169 http://dx.doi.org/10.1155/2009/841468 |
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author | Sheikh, Nasrin Tavilani, Heidar Rezaie, Aliakbar Vaisi-raygani, Asad Salimi, Saeedeh |
author_facet | Sheikh, Nasrin Tavilani, Heidar Rezaie, Aliakbar Vaisi-raygani, Asad Salimi, Saeedeh |
author_sort | Sheikh, Nasrin |
collection | PubMed |
description | Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P < .05, P < .001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r = −0.54, P = .029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity. |
format | Text |
id | pubmed-2737135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27371352009-09-09 Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke Sheikh, Nasrin Tavilani, Heidar Rezaie, Aliakbar Vaisi-raygani, Asad Salimi, Saeedeh J Biomed Biotechnol Research Article Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P < .05, P < .001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r = −0.54, P = .029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity. Hindawi Publishing Corporation 2009 2009-09-02 /pmc/articles/PMC2737135/ /pubmed/19746169 http://dx.doi.org/10.1155/2009/841468 Text en Copyright © 2009 Nasrin Sheikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sheikh, Nasrin Tavilani, Heidar Rezaie, Aliakbar Vaisi-raygani, Asad Salimi, Saeedeh Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title | Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title_full | Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title_fullStr | Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title_full_unstemmed | Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title_short | Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke |
title_sort | relationship between estradiol and antioxidant enzymes activity of ischemic stroke |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737135/ https://www.ncbi.nlm.nih.gov/pubmed/19746169 http://dx.doi.org/10.1155/2009/841468 |
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