Revisiting Crohn's disease as a primary immunodeficiency of macrophages

Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall...

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Detalles Bibliográficos
Autores principales: Casanova, Jean-Laurent, Abel, Laurent
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737171/
https://www.ncbi.nlm.nih.gov/pubmed/19687225
http://dx.doi.org/10.1084/jem.20091683
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author Casanova, Jean-Laurent
Abel, Laurent
author_facet Casanova, Jean-Laurent
Abel, Laurent
author_sort Casanova, Jean-Laurent
collection PubMed
description Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall, causing impaired clearance of intruding bacteria, thereby precipitating the formation of granulomas. This theory paves the way for a macrophage-based Mendelian genetic dissection of CD.
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spelling pubmed-27371712010-02-28 Revisiting Crohn's disease as a primary immunodeficiency of macrophages Casanova, Jean-Laurent Abel, Laurent J Exp Med Commentary Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall, causing impaired clearance of intruding bacteria, thereby precipitating the formation of granulomas. This theory paves the way for a macrophage-based Mendelian genetic dissection of CD. The Rockefeller University Press 2009-08-31 /pmc/articles/PMC2737171/ /pubmed/19687225 http://dx.doi.org/10.1084/jem.20091683 Text en © 2009 Casanova and Abel This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Casanova, Jean-Laurent
Abel, Laurent
Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title_full Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title_fullStr Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title_full_unstemmed Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title_short Revisiting Crohn's disease as a primary immunodeficiency of macrophages
title_sort revisiting crohn's disease as a primary immunodeficiency of macrophages
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737171/
https://www.ncbi.nlm.nih.gov/pubmed/19687225
http://dx.doi.org/10.1084/jem.20091683
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