Design of efficient DNAzymes against muscle AChR α-subunit cRNA in vitro and in HEK 293 cells

DNAzymes are catalytic DNA which bind to target RNA by complementary sequence arms on a Watson-Crick basis and cleave RNA at specific sites. Potential therapeutic applications require DNAzymes that can efficiently cleave their target. Here we investigate factors affecting DNAzyme cleavage efficacy a...

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Detalles Bibliográficos
Autores principales: Abdelgany, Amr, Uddin, M Khabir, Wood, Matthew, Taira, Kazunari, Beeson, David
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737201/
https://www.ncbi.nlm.nih.gov/pubmed/19771209

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