Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region

In addition to the degradation of homologous RNAs through the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) can in some systems induce cytosine methylation and transcriptional silencing of homologous promoters. Targeting of HIV-1 by RNAi results in transient suppression of the vir...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazuo, Shijuuku, Toshiaki, Fukamachi, Toshihiko, Zaunders, John, Guillemin, Gilles, Cooper, David, Kelleher, Anthony
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737205/
https://www.ncbi.nlm.nih.gov/pubmed/19771207

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