Designer siRNAs to overcome the challenges from the RNAi pathway

Small interfering RNA (siRNA)-based technology is playing a pivotal role in understanding gene function. Huge siRNA libraries coupled to high-content screening are being applied to decipher molecular circuitries, as well as to identify novel therapeutic targets. Further, the technology is finding it...

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Detalles Bibliográficos
Autor principal: Jayasena, Sumedha D
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737206/
https://www.ncbi.nlm.nih.gov/pubmed/19771212
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author Jayasena, Sumedha D
author_facet Jayasena, Sumedha D
author_sort Jayasena, Sumedha D
collection PubMed
description Small interfering RNA (siRNA)-based technology is playing a pivotal role in understanding gene function. Huge siRNA libraries coupled to high-content screening are being applied to decipher molecular circuitries, as well as to identify novel therapeutic targets. Further, the technology is finding its way towards therapeutic applications. In the midst of all this excitement, the siRNA technology is faced with challenges, arising mostly from siRNAs being a nucleic acid molecule, and also from the baggage it inherits from the RNA interference (RNAi) pathway, which is critical to the function of siRNAs.
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spelling pubmed-27372062009-09-21 Designer siRNAs to overcome the challenges from the RNAi pathway Jayasena, Sumedha D J RNAi Gene Silencing Review Article Small interfering RNA (siRNA)-based technology is playing a pivotal role in understanding gene function. Huge siRNA libraries coupled to high-content screening are being applied to decipher molecular circuitries, as well as to identify novel therapeutic targets. Further, the technology is finding its way towards therapeutic applications. In the midst of all this excitement, the siRNA technology is faced with challenges, arising mostly from siRNAs being a nucleic acid molecule, and also from the baggage it inherits from the RNA interference (RNAi) pathway, which is critical to the function of siRNAs. Library Publishing Media 2005-11-30 /pmc/articles/PMC2737206/ /pubmed/19771212 Text en © Copyright Sumedha D Jayasena http://www.libpubmedia.co.uk/RNAiJ/LicenceForUsers.pdf This is an open access article, published under the terms of the Licence for Users available at http://www.libpubmedia.co.uk/RNAiJ/LicenceForUsers.pdf. This licence permits noncommercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.
spellingShingle Review Article
Jayasena, Sumedha D
Designer siRNAs to overcome the challenges from the RNAi pathway
title Designer siRNAs to overcome the challenges from the RNAi pathway
title_full Designer siRNAs to overcome the challenges from the RNAi pathway
title_fullStr Designer siRNAs to overcome the challenges from the RNAi pathway
title_full_unstemmed Designer siRNAs to overcome the challenges from the RNAi pathway
title_short Designer siRNAs to overcome the challenges from the RNAi pathway
title_sort designer sirnas to overcome the challenges from the rnai pathway
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737206/
https://www.ncbi.nlm.nih.gov/pubmed/19771212
work_keys_str_mv AT jayasenasumedhad designersirnastoovercomethechallengesfromthernaipathway

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