Long-term transgene expression and inhibition of HIV-1 replication by a Cre/loxP-EBNA-1/oriP HIV-1-dependent ribozyme vector: Applications for HIV-1 gene therapy

The cleavage of target mRNA by ribozymes is being exploited as a means of gene silencing in nucleic-acid-based therapies. We previously established an HIV-1-dependent ribozyme-expression vector system, based on Cre-loxP technology with an LTR-gag-p17 promoter as a molecular switch for use in acute H...

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Detalles Bibliográficos
Autores principales: Nagawa, Takashi, Habu, Yuichiro, Matsumoto, Norihiko, Miyano-Kurosaki, Naoko, Takaku, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2006
Materias:
New Methods and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737208/
https://www.ncbi.nlm.nih.gov/pubmed/19771216

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