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Native microRNA loop sequences can improve short hairpin RNA processing for virus gene silencing in animal cells

Introduction of small interfering RNAs (siRNAs) into cells results in transitory silencing of target genes with complementary sequence. Incorporating siRNAs into short-hairpin RNAs (shRNAs) or microRNA-adapted shRNAs (shRNAmir) is a popular tool for targeted gene silencing. shRNAmirs mimicking endog...

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Detalles Bibliográficos
Autores principales:	Hinton, Tracey M, Wise, Terry G, Cottee, Pauline A, Doran, Timothy J
Formato:	Texto
Lenguaje:	English
Publicado:	Library Publishing Media 2008
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737240/ https://www.ncbi.nlm.nih.gov/pubmed/19771239

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