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Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice
BACKGROUND: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of ne...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737283/ https://www.ncbi.nlm.nih.gov/pubmed/19753118 http://dx.doi.org/10.1371/journal.pone.0007017 |
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author | Lazarini, Françoise Mouthon, Marc-André Gheusi, Gilles de Chaumont, Fabrice Olivo-Marin, Jean-Christophe Lamarque, Stéphanie Abrous, Djoher Nora Boussin, François D. Lledo, Pierre-Marie |
author_facet | Lazarini, Françoise Mouthon, Marc-André Gheusi, Gilles de Chaumont, Fabrice Olivo-Marin, Jean-Christophe Lamarque, Stéphanie Abrous, Djoher Nora Boussin, François D. Lledo, Pierre-Marie |
author_sort | Lazarini, Françoise |
collection | PubMed |
description | BACKGROUND: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation. CONCLUSION/SIGNIFICANCE: These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces. |
format | Text |
id | pubmed-2737283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-27372832009-09-15 Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice Lazarini, Françoise Mouthon, Marc-André Gheusi, Gilles de Chaumont, Fabrice Olivo-Marin, Jean-Christophe Lamarque, Stéphanie Abrous, Djoher Nora Boussin, François D. Lledo, Pierre-Marie PLoS One Research Article BACKGROUND: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation. CONCLUSION/SIGNIFICANCE: These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces. Public Library of Science 2009-09-15 /pmc/articles/PMC2737283/ /pubmed/19753118 http://dx.doi.org/10.1371/journal.pone.0007017 Text en Lazarini et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lazarini, Françoise Mouthon, Marc-André Gheusi, Gilles de Chaumont, Fabrice Olivo-Marin, Jean-Christophe Lamarque, Stéphanie Abrous, Djoher Nora Boussin, François D. Lledo, Pierre-Marie Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title | Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title_full | Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title_fullStr | Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title_full_unstemmed | Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title_short | Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice |
title_sort | cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737283/ https://www.ncbi.nlm.nih.gov/pubmed/19753118 http://dx.doi.org/10.1371/journal.pone.0007017 |
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