Oxidative stress, thermogenesis and evolution of uncoupling proteins

The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying se...

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Detalles Bibliográficos
Autores principales: Rial, Eduardo, Zardoya, Rafael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737370/
https://www.ncbi.nlm.nih.gov/pubmed/19589183
http://dx.doi.org/10.1186/jbiol155
Descripción
Sumario:The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.

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