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Thigh circumference and risk of heart disease and premature death: prospective cohort study

Objective To examine associations between thigh circumference and incident cardiovascular disease and coronary heart disease and total mortality. Design Prospective observational cohort study with Cox proportional hazards model and restricted cubic splines. Setting Random subset of adults in Denmark...

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Detalles Bibliográficos
Autores principales: Heitmann, Berit L, Frederiksen, Peder
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737606/
https://www.ncbi.nlm.nih.gov/pubmed/19729416
http://dx.doi.org/10.1136/bmj.b3292
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author Heitmann, Berit L
Frederiksen, Peder
author_facet Heitmann, Berit L
Frederiksen, Peder
author_sort Heitmann, Berit L
collection PubMed
description Objective To examine associations between thigh circumference and incident cardiovascular disease and coronary heart disease and total mortality. Design Prospective observational cohort study with Cox proportional hazards model and restricted cubic splines. Setting Random subset of adults in Denmark. Participants 1436 men and 1380 women participating in the Danish MONICA project, examined in 1987-8 for height, weight, and thigh, hip, and waist circumference, and body composition by impedance. Main outcome measures 10 year incidence of cardiovascular and coronary heart disease and 12.5 years of follow-up for total death. Results A small thigh circumference was associated with an increased risk of cardiovascular and coronary heart diseases and total mortality in both men and women. A threshold effect for thigh circumference was evident, with greatly increased risk of premature death below around 60 cm. Above the threshold there seemed to be no additional benefit of having larger thighs in either sex. These findings were independent of abdominal and general obesity, lifestyle, and cardiovascular risk factors such as blood pressure and lipid concentration. Conclusion A low thigh circumference seems to be associated with an increased risk of developing heart disease or premature death. The adverse effects of small thighs might be related to too little muscle mass in the region. The measure of thigh circumference might be a relevant anthropometric measure to help general practitioners in early identification of individuals at an increased risk of premature morbidity and mortality.
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spelling pubmed-27376062009-09-04 Thigh circumference and risk of heart disease and premature death: prospective cohort study Heitmann, Berit L Frederiksen, Peder BMJ Research Objective To examine associations between thigh circumference and incident cardiovascular disease and coronary heart disease and total mortality. Design Prospective observational cohort study with Cox proportional hazards model and restricted cubic splines. Setting Random subset of adults in Denmark. Participants 1436 men and 1380 women participating in the Danish MONICA project, examined in 1987-8 for height, weight, and thigh, hip, and waist circumference, and body composition by impedance. Main outcome measures 10 year incidence of cardiovascular and coronary heart disease and 12.5 years of follow-up for total death. Results A small thigh circumference was associated with an increased risk of cardiovascular and coronary heart diseases and total mortality in both men and women. A threshold effect for thigh circumference was evident, with greatly increased risk of premature death below around 60 cm. Above the threshold there seemed to be no additional benefit of having larger thighs in either sex. These findings were independent of abdominal and general obesity, lifestyle, and cardiovascular risk factors such as blood pressure and lipid concentration. Conclusion A low thigh circumference seems to be associated with an increased risk of developing heart disease or premature death. The adverse effects of small thighs might be related to too little muscle mass in the region. The measure of thigh circumference might be a relevant anthropometric measure to help general practitioners in early identification of individuals at an increased risk of premature morbidity and mortality. BMJ Publishing Group Ltd. 2009-09-03 /pmc/articles/PMC2737606/ /pubmed/19729416 http://dx.doi.org/10.1136/bmj.b3292 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
Heitmann, Berit L
Frederiksen, Peder
Thigh circumference and risk of heart disease and premature death: prospective cohort study
title Thigh circumference and risk of heart disease and premature death: prospective cohort study
title_full Thigh circumference and risk of heart disease and premature death: prospective cohort study
title_fullStr Thigh circumference and risk of heart disease and premature death: prospective cohort study
title_full_unstemmed Thigh circumference and risk of heart disease and premature death: prospective cohort study
title_short Thigh circumference and risk of heart disease and premature death: prospective cohort study
title_sort thigh circumference and risk of heart disease and premature death: prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737606/
https://www.ncbi.nlm.nih.gov/pubmed/19729416
http://dx.doi.org/10.1136/bmj.b3292
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