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Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients

BACKGROUND AND AIM: It is well known that dialysis dependent renal failure increases the likelihood of poor outcome following cardiac surgery. But the results of CABG in patients with mild renal dysfunction are not clearly established. The aim of the study is to analyze the risk of preoperative mild...

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Autores principales: Ramakrishna, M. N., Hegde, V. Deviprasad, Kumarswamy, G. N., Gupta, Ratan, Moola, Narayana Swamy, Suresh, K. P.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738323/
https://www.ncbi.nlm.nih.gov/pubmed/19742264
http://dx.doi.org/10.4103/0972-5229.45075
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author Ramakrishna, M. N.
Hegde, V. Deviprasad
Kumarswamy, G. N.
Gupta, Ratan
Moola, Narayana Swamy
Suresh, K. P.
author_facet Ramakrishna, M. N.
Hegde, V. Deviprasad
Kumarswamy, G. N.
Gupta, Ratan
Moola, Narayana Swamy
Suresh, K. P.
author_sort Ramakrishna, M. N.
collection PubMed
description BACKGROUND AND AIM: It is well known that dialysis dependent renal failure increases the likelihood of poor outcome following cardiac surgery. But the results of CABG in patients with mild renal dysfunction are not clearly established. The aim of the study is to analyze the risk of preoperative mild renal dysfunction on outcome after isolated coronary surgery. MATERIALS AND METHODS: We reviewed prospectively collected data between June 2006-Nov 2006 in 488 patients who underwent isolated CABG. We separated the data into two groups. Control group having normal renal function and study group having mild renal dysfunction (serum creatinine 1.4 mg-2.2 mg%). Among 488 patients, 412 patients were in control group and 76 patients were in the study group. RESULTS: Analysis of data showed significant postoperative complications in the mild renal dysfunction group, like increased operative mortality (7.5% vs 1.6%), increased requirement of postoperative renal replacement therapy (10% vs 1.2%), increased incidence of new onset atrial fibrillation (20% vs 4.2%) and prolonged duration of ICU stay. Multivariate analysis adjusting for known risk factors confirmed preoperative mild renal dysfunction (S.creat.1.4-2.2 mg/dl) is an independent risk factor for postoperative morbidity and mortality. (Adj. OR: 4.47; 95% CI: 1.41-14.16; P=0.010). CONCLUSION: Mild renal dysfunction is an important independent predictor of outcome in terms of in-hospital mortality and morbidity in patients undergoing CABG.
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spelling pubmed-27383232009-09-08 Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients Ramakrishna, M. N. Hegde, V. Deviprasad Kumarswamy, G. N. Gupta, Ratan Moola, Narayana Swamy Suresh, K. P. Indian J Crit Care Med Original Article BACKGROUND AND AIM: It is well known that dialysis dependent renal failure increases the likelihood of poor outcome following cardiac surgery. But the results of CABG in patients with mild renal dysfunction are not clearly established. The aim of the study is to analyze the risk of preoperative mild renal dysfunction on outcome after isolated coronary surgery. MATERIALS AND METHODS: We reviewed prospectively collected data between June 2006-Nov 2006 in 488 patients who underwent isolated CABG. We separated the data into two groups. Control group having normal renal function and study group having mild renal dysfunction (serum creatinine 1.4 mg-2.2 mg%). Among 488 patients, 412 patients were in control group and 76 patients were in the study group. RESULTS: Analysis of data showed significant postoperative complications in the mild renal dysfunction group, like increased operative mortality (7.5% vs 1.6%), increased requirement of postoperative renal replacement therapy (10% vs 1.2%), increased incidence of new onset atrial fibrillation (20% vs 4.2%) and prolonged duration of ICU stay. Multivariate analysis adjusting for known risk factors confirmed preoperative mild renal dysfunction (S.creat.1.4-2.2 mg/dl) is an independent risk factor for postoperative morbidity and mortality. (Adj. OR: 4.47; 95% CI: 1.41-14.16; P=0.010). CONCLUSION: Mild renal dysfunction is an important independent predictor of outcome in terms of in-hospital mortality and morbidity in patients undergoing CABG. Medknow Publications 2008 /pmc/articles/PMC2738323/ /pubmed/19742264 http://dx.doi.org/10.4103/0972-5229.45075 Text en © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ramakrishna, M. N.
Hegde, V. Deviprasad
Kumarswamy, G. N.
Gupta, Ratan
Moola, Narayana Swamy
Suresh, K. P.
Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title_full Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title_fullStr Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title_full_unstemmed Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title_short Impact of preoperative mild renal dysfunction on short term outcome in isolated Coronary Artery Bypass (CABG) patients
title_sort impact of preoperative mild renal dysfunction on short term outcome in isolated coronary artery bypass (cabg) patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738323/
https://www.ncbi.nlm.nih.gov/pubmed/19742264
http://dx.doi.org/10.4103/0972-5229.45075
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