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Clinical Epidemiology of Malaria in the Highlands of Western Kenya

Malaria in the highlands of Kenya is traditionally regarded as unstable and limited by low temperature. Brief warm periods may facilitate malaria transmission and are therefore able to generate epidemic conditions in immunologically naive human populations living at high altitudes. The adult:child r...

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Detalles Bibliográficos
Autores principales: Hay, Simon I., Noor, Abdisalan M., Simba, Milka, Busolo, Millie, Guyatt, Helen L., Ochola, Sam A., Snow, Robert W.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738495/
https://www.ncbi.nlm.nih.gov/pubmed/12023907
http://dx.doi.org/10.3201/eid0806.010309
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author Hay, Simon I.
Noor, Abdisalan M.
Simba, Milka
Busolo, Millie
Guyatt, Helen L.
Ochola, Sam A.
Snow, Robert W.
author_facet Hay, Simon I.
Noor, Abdisalan M.
Simba, Milka
Busolo, Millie
Guyatt, Helen L.
Ochola, Sam A.
Snow, Robert W.
author_sort Hay, Simon I.
collection PubMed
description Malaria in the highlands of Kenya is traditionally regarded as unstable and limited by low temperature. Brief warm periods may facilitate malaria transmission and are therefore able to generate epidemic conditions in immunologically naive human populations living at high altitudes. The adult:child ratio (ACR) of malaria admissions is a simple tool we have used to assess the degree of functional immunity in the catchment population of a health facility. Examples of ACR are collected from inpatient admission data at facilities with a range of malaria endemicities in Kenya. Two decades of inpatient malaria admission data from three health facilities in a high-altitude area of western Kenya do not support the canonical view of unstable transmission. The malaria of the region is best described as seasonal and meso-endemic. We discuss the implications for malaria control options in the Kenyan highlands.
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spelling pubmed-27384952009-09-16 Clinical Epidemiology of Malaria in the Highlands of Western Kenya Hay, Simon I. Noor, Abdisalan M. Simba, Milka Busolo, Millie Guyatt, Helen L. Ochola, Sam A. Snow, Robert W. Emerg Infect Dis Perspective Malaria in the highlands of Kenya is traditionally regarded as unstable and limited by low temperature. Brief warm periods may facilitate malaria transmission and are therefore able to generate epidemic conditions in immunologically naive human populations living at high altitudes. The adult:child ratio (ACR) of malaria admissions is a simple tool we have used to assess the degree of functional immunity in the catchment population of a health facility. Examples of ACR are collected from inpatient admission data at facilities with a range of malaria endemicities in Kenya. Two decades of inpatient malaria admission data from three health facilities in a high-altitude area of western Kenya do not support the canonical view of unstable transmission. The malaria of the region is best described as seasonal and meso-endemic. We discuss the implications for malaria control options in the Kenyan highlands. Centers for Disease Control and Prevention 2002-06 /pmc/articles/PMC2738495/ /pubmed/12023907 http://dx.doi.org/10.3201/eid0806.010309 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Perspective
Hay, Simon I.
Noor, Abdisalan M.
Simba, Milka
Busolo, Millie
Guyatt, Helen L.
Ochola, Sam A.
Snow, Robert W.
Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title_full Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title_fullStr Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title_full_unstemmed Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title_short Clinical Epidemiology of Malaria in the Highlands of Western Kenya
title_sort clinical epidemiology of malaria in the highlands of western kenya
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738495/
https://www.ncbi.nlm.nih.gov/pubmed/12023907
http://dx.doi.org/10.3201/eid0806.010309
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