Cargando…

Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry

[Image: see text] The lantibiotic synthetases LctM and HalM2 are bifunctional enzymes that catalyze both the dehydration of serine and threonine residues and the Michael-type additions of cysteine residues to the resulting dehydroamino acids in their substrate peptides. Using Fourier transform mass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, M. Violet, Ihnken, Leigh Anne Furgerson, You, Young Ok, McClerren, Amanda L., Donk, Wilfred A. van der, Kelleher, Neil L.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2009
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738757/ https://www.ncbi.nlm.nih.gov/pubmed/19663480 http://dx.doi.org/10.1021/ja9033507

Ejemplares similares

Lacticin 481 Synthetase as a General Serine/Threonine Kinase
por: You, Young Ok, et al.
Publicado: (2009)

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate
por: Oman, Trent J., et al.
Publicado: (2012)

Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin
por: Oman, Trent J., et al.
Publicado: (2009)

Sublancin is not a lantibiotic but an S-linked glycopeptide
por: Oman, Trent J., et al.
Publicado: (2011)

Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X
por: Knerr, Patrick J., et al.
Publicado: (2012)

Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry
por: Knerr, Patrick J., et al.
Publicado: (2013)

Mechanism of Inhibition of Bacillus anthracis Spore Outgrowth by the Lantibiotic Nisin
por: Gut, Ian M., et al.
Publicado: (2011)

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids
por: Levengood, Matthew R., et al.
Publicado: (2009)

Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic
por: Huo, Liujie, et al.
Publicado: (2016)

In Vitro Characterization of a Heterologously Expressed Nonribosomal Peptide Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis
por: Lee, Jin-Hee, et al.
Publicado: (2009)

Mechanistic Studies on the Substrate-Tolerant Lanthipeptide Synthetase ProcM
por: Mukherjee, Subha, et al.
Publicado: (2014)

An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase
por: Thibodeaux, Gabrielle N., et al.
Publicado: (2012)

Bioengineering Lantibiotics for Therapeutic Success
por: Field, Des, et al.
Publicado: (2015)

Bovicin HJ50-Like Lantibiotics, a Novel Subgroup of Lantibiotics Featured by an Indispensable Disulfide Bridge
por: Wang, Jian, et al.
Publicado: (2014)

Mechanistic Studies of Ser/Thr Dehydration Catalyzed by a Member of the LanL Lanthionine Synthetase Family†
por: Goto, Yuki, et al.
Publicado: (2011)

Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt
por: Zeng, Min, et al.
Publicado: (2014)

Incorporation of tryptophan analogues into the lantibiotic nisin
por: Zhou, Liang, et al.
Publicado: (2016)

Elucidation of the Bridging Pattern of the Lantibiotic Pseudomycoicidin
por: Janssen, Kathrin, et al.
Publicado: (2022)

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
por: Dong, Shi-Hui, et al.
Publicado: (2015)

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights
por: Goto, Yuki, et al.
Publicado: (2010)

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin
por: Appleyard, Antony N., et al.
Publicado: (2009)

Stoichiometry and structure of a lantibiotic maturation complex
por: Reiners, Jens, et al.
Publicado: (2017)

Specificity and Application of the Lantibiotic Protease NisP
por: Montalbán-López, Manuel, et al.
Publicado: (2018)

Fighting biofilms with lantibiotics and other groups of bacteriocins
por: Mathur, Harsh, et al.
Publicado: (2018)

Lantibiotic production is a burden for the producing staphylococci
por: Ebner, Patrick, et al.
Publicado: (2018)

The antiplaque efficacy of lantibiotic Nisin extract mouthrinse
por: Mitra, Dipika, et al.
Publicado: (2019)

First evidence of production of the lantibiotic nisin P
por: Garcia-Gutierrez, Enriqueta, et al.
Publicado: (2020)

Identification of Microorganisms by High Resolution Tandem Mass Spectrometry with Accurate Statistical Significance
por: Alves, Gelio, et al.
Publicado: (2015)

Bone protein “extractomics”: comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics
por: Schroeter, Elena R., et al.
Publicado: (2016)

Gas-Phase Fragmentation Reactions of Protonated Cystine using High-Resolution Tandem Mass Spectrometry
por: Zhang, Pengwei, et al.
Publicado: (2019)

A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2
por: Thibodeaux, Christopher J., et al.
Publicado: (2014)

Expression of the Lantibiotic Mersacidin in Bacillus amyloliquefaciens FZB42
por: Herzner, Anna Maria, et al.
Publicado: (2011)

Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae
por: Maricic, Natalie, et al.
Publicado: (2016)

New insights into the mode of action of the lantibiotic salivaricin B
por: Barbour, Abdelahhad, et al.
Publicado: (2016)

Structure, dynamics and kinetics of two-component Lantibiotic Lichenicidin
por: de Miguel, Alejandra, et al.
Publicado: (2017)

MiniBacillus PG10 as a Convenient and Effective Production Host for Lantibiotics
por: van Tilburg, Amanda Y., et al.
Publicado: (2020)

Processing and Structure of the Lantibiotic Peptide Nso From the Human Gut Bacterium Blautia obeum A2-162 analysed by Mass Spectrometry
por: Gherghisan-Filip, Cristina, et al.
Publicado: (2018)

Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry
por: Abdelrazig, Salah, et al.
Publicado: (2021)

Characterization of Triacylglycerol Estolide Isomers Using High-Resolution Tandem Mass Spectrometry with Nanoelectrospray Ionization
por: Cudlman, Lukáš, et al.
Publicado: (2023)

Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance
por: Clemens, Rebecca, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9ncp5rv42eoil2pqleqv5l9h55