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Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSS...

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Detalles Bibliográficos
Autores principales:	Simons, Andrean L., Parsons, Arlene D., Foster, Katherine A., Orcutt, Kevin P., Fath, Melissa A., Spitz, Douglas R.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738856/ https://www.ncbi.nlm.nih.gov/pubmed/19746172 http://dx.doi.org/10.1155/2009/519563

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