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Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features

We assessed a set of biological (HDL, LDL, SGOT, SGPT, GGT, HTc, Hb and T levels) and psychometric variables (investigated through HAM-D, HAM-A, GAS, Liebowitz Social Anxiety Scale, Mark & Mathews Scale, Leyton scale, and Pilowski scale) in a sample of 64 alcohol dependent patients, at baseline...

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Detalles Bibliográficos
Autores principales: Drago, Antonio, Liappas, Ioannis, Petio, Carmine, Albani, Diego, Forloni, Gianluigi, Malitas, Petros, Piperi, Christina, Politis, Antonis, Tzavellas, Elias O., Zisaki, Katerina K., Prato, Francesca, Batelli, Sara, Polito, Letizia, De Ronchi, Diana, Paparrigopoulos, Thomas, Kalofoutis, Anastasios, Serretti, Alessandro
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738893/
https://www.ncbi.nlm.nih.gov/pubmed/19742166
http://dx.doi.org/10.3390/ijerph6071980
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author Drago, Antonio
Liappas, Ioannis
Petio, Carmine
Albani, Diego
Forloni, Gianluigi
Malitas, Petros
Piperi, Christina
Politis, Antonis
Tzavellas, Elias O.
Zisaki, Katerina K.
Prato, Francesca
Batelli, Sara
Polito, Letizia
De Ronchi, Diana
Paparrigopoulos, Thomas
Kalofoutis, Anastasios
Serretti, Alessandro
author_facet Drago, Antonio
Liappas, Ioannis
Petio, Carmine
Albani, Diego
Forloni, Gianluigi
Malitas, Petros
Piperi, Christina
Politis, Antonis
Tzavellas, Elias O.
Zisaki, Katerina K.
Prato, Francesca
Batelli, Sara
Polito, Letizia
De Ronchi, Diana
Paparrigopoulos, Thomas
Kalofoutis, Anastasios
Serretti, Alessandro
author_sort Drago, Antonio
collection PubMed
description We assessed a set of biological (HDL, LDL, SGOT, SGPT, GGT, HTc, Hb and T levels) and psychometric variables (investigated through HAM-D, HAM-A, GAS, Liebowitz Social Anxiety Scale, Mark & Mathews Scale, Leyton scale, and Pilowski scale) in a sample of 64 alcohol dependent patients, at baseline and after a detoxification treatment. Moreover, we recruited 47 non-consanguineous relatives who did not suffer alcohol related disorders and underwent the same tests. In both groups we genotyped 11 genetic variations (rs1800587; rs3087258; rs1799724; 5-HTTLPR; rs1386493; rs1386494; rs1487275; rs1843809; rs4570625; rs2129575; rs6313) located in genes whose impact on alcohol related behaviors and disorders has been hypothesized (IL1A, IL1B, TNF, 5-HTTLPR, TPH2 and HTR2A). We analyzed the epistasis of these genetic variations upon the biological and psychological dimensions in the cases and their relatives. Further on, we analyzed the effects of the combined genetic variations on the short – term detoxification treatment efficacy. Finally, being the only not yet investigated variation within this sample, we analyzed the impact of the rs6313 alone on baseline assessment and treatment efficacy. We detected the following results: the couple rs6313 + rs2129575 affected the Leyton -Trait at admission (p = 0.01) (obsessive-compulsive trait), whilst rs1800587 + 5-HTTLPR impacted the Pilowski test at admission (p = 0.01) (hypochondriac symptoms). These results did not survive Bonferroni correction (p ≤ 0.004). This lack of association may depend on the incomplete gene coverage or on the small sample size which limited the power of the study. On the other hand, it may reflect a substantial absence of relevance of the genotype variants toward the alcohol related investigated dimensions. Nonetheless, the marginal significance we detected could witness an informative correlation worth investigating in larger samples.
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spelling pubmed-27388932009-09-08 Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features Drago, Antonio Liappas, Ioannis Petio, Carmine Albani, Diego Forloni, Gianluigi Malitas, Petros Piperi, Christina Politis, Antonis Tzavellas, Elias O. Zisaki, Katerina K. Prato, Francesca Batelli, Sara Polito, Letizia De Ronchi, Diana Paparrigopoulos, Thomas Kalofoutis, Anastasios Serretti, Alessandro Int J Environ Res Public Health Article We assessed a set of biological (HDL, LDL, SGOT, SGPT, GGT, HTc, Hb and T levels) and psychometric variables (investigated through HAM-D, HAM-A, GAS, Liebowitz Social Anxiety Scale, Mark & Mathews Scale, Leyton scale, and Pilowski scale) in a sample of 64 alcohol dependent patients, at baseline and after a detoxification treatment. Moreover, we recruited 47 non-consanguineous relatives who did not suffer alcohol related disorders and underwent the same tests. In both groups we genotyped 11 genetic variations (rs1800587; rs3087258; rs1799724; 5-HTTLPR; rs1386493; rs1386494; rs1487275; rs1843809; rs4570625; rs2129575; rs6313) located in genes whose impact on alcohol related behaviors and disorders has been hypothesized (IL1A, IL1B, TNF, 5-HTTLPR, TPH2 and HTR2A). We analyzed the epistasis of these genetic variations upon the biological and psychological dimensions in the cases and their relatives. Further on, we analyzed the effects of the combined genetic variations on the short – term detoxification treatment efficacy. Finally, being the only not yet investigated variation within this sample, we analyzed the impact of the rs6313 alone on baseline assessment and treatment efficacy. We detected the following results: the couple rs6313 + rs2129575 affected the Leyton -Trait at admission (p = 0.01) (obsessive-compulsive trait), whilst rs1800587 + 5-HTTLPR impacted the Pilowski test at admission (p = 0.01) (hypochondriac symptoms). These results did not survive Bonferroni correction (p ≤ 0.004). This lack of association may depend on the incomplete gene coverage or on the small sample size which limited the power of the study. On the other hand, it may reflect a substantial absence of relevance of the genotype variants toward the alcohol related investigated dimensions. Nonetheless, the marginal significance we detected could witness an informative correlation worth investigating in larger samples. Molecular Diversity Preservation International (MDPI) 2009-07 2009-07-16 /pmc/articles/PMC2738893/ /pubmed/19742166 http://dx.doi.org/10.3390/ijerph6071980 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Drago, Antonio
Liappas, Ioannis
Petio, Carmine
Albani, Diego
Forloni, Gianluigi
Malitas, Petros
Piperi, Christina
Politis, Antonis
Tzavellas, Elias O.
Zisaki, Katerina K.
Prato, Francesca
Batelli, Sara
Polito, Letizia
De Ronchi, Diana
Paparrigopoulos, Thomas
Kalofoutis, Anastasios
Serretti, Alessandro
Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title_full Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title_fullStr Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title_full_unstemmed Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title_short Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations Does Not Impact Alcohol Dependence Disorder Features
title_sort epistasis between il1a, il1b, tnf, htr2a, 5-httlpr and tph2 variations does not impact alcohol dependence disorder features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738893/
https://www.ncbi.nlm.nih.gov/pubmed/19742166
http://dx.doi.org/10.3390/ijerph6071980
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