The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids

Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause ins...

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Autores principales: de la Monte, Suzanne M., Longato, Lisa, Tong, Ming, DeNucci, Sarah, Wands, Jack R.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738898/
https://www.ncbi.nlm.nih.gov/pubmed/19742171
http://dx.doi.org/10.3390/ijerph6072055
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author de la Monte, Suzanne M.
Longato, Lisa
Tong, Ming
DeNucci, Sarah
Wands, Jack R.
author_facet de la Monte, Suzanne M.
Longato, Lisa
Tong, Ming
DeNucci, Sarah
Wands, Jack R.
author_sort de la Monte, Suzanne M.
collection PubMed
description Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause insulin resistance. Ceramides can readily cross the blood-brain barrier, and ceramide exposure causes neurodegeneration with insulin resistance and oxidative stress, similar to the effects of alcohol. Therefore, in addition to its direct neurotoxic effects, alcohol misuse establishes a liver-brain axis of neurodegeneration mediated by toxic lipid trafficking across the blood-brain barrier, leading to progressive white matter degeneration and cognitive impairment.
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spelling pubmed-27388982009-09-08 The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids de la Monte, Suzanne M. Longato, Lisa Tong, Ming DeNucci, Sarah Wands, Jack R. Int J Environ Res Public Health Article Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause insulin resistance. Ceramides can readily cross the blood-brain barrier, and ceramide exposure causes neurodegeneration with insulin resistance and oxidative stress, similar to the effects of alcohol. Therefore, in addition to its direct neurotoxic effects, alcohol misuse establishes a liver-brain axis of neurodegeneration mediated by toxic lipid trafficking across the blood-brain barrier, leading to progressive white matter degeneration and cognitive impairment. Molecular Diversity Preservation International (MDPI) 2009-07 2009-07-23 /pmc/articles/PMC2738898/ /pubmed/19742171 http://dx.doi.org/10.3390/ijerph6072055 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
de la Monte, Suzanne M.
Longato, Lisa
Tong, Ming
DeNucci, Sarah
Wands, Jack R.
The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title_full The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title_fullStr The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title_full_unstemmed The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title_short The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
title_sort liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738898/
https://www.ncbi.nlm.nih.gov/pubmed/19742171
http://dx.doi.org/10.3390/ijerph6072055
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