The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PL...

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Autores principales: Cieślik, Magdalena, Mertas, Anna, Morawska-Chochólł, Anna, Sabat, Daniel, Orlicki, Rajmund, Owczarek, Aleksander, Król, Wojciech, Cieślik, Tadeusz
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738921/
https://www.ncbi.nlm.nih.gov/pubmed/19742134
http://dx.doi.org/10.3390/ijms10073224
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author Cieślik, Magdalena
Mertas, Anna
Morawska-Chochólł, Anna
Sabat, Daniel
Orlicki, Rajmund
Owczarek, Aleksander
Król, Wojciech
Cieślik, Tadeusz
author_facet Cieślik, Magdalena
Mertas, Anna
Morawska-Chochólł, Anna
Sabat, Daniel
Orlicki, Rajmund
Owczarek, Aleksander
Król, Wojciech
Cieślik, Tadeusz
author_sort Cieślik, Magdalena
collection PubMed
description Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.
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spelling pubmed-27389212009-09-08 The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations Cieślik, Magdalena Mertas, Anna Morawska-Chochólł, Anna Sabat, Daniel Orlicki, Rajmund Owczarek, Aleksander Król, Wojciech Cieślik, Tadeusz Int J Mol Sci Article Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible. Molecular Diversity Preservation International (MDPI) 2009-07-15 /pmc/articles/PMC2738921/ /pubmed/19742134 http://dx.doi.org/10.3390/ijms10073224 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cieślik, Magdalena
Mertas, Anna
Morawska-Chochólł, Anna
Sabat, Daniel
Orlicki, Rajmund
Owczarek, Aleksander
Król, Wojciech
Cieślik, Tadeusz
The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title_full The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title_fullStr The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title_full_unstemmed The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title_short The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations
title_sort evaluation of the possibilities of using plga co-polymer and its composites with carbon fibers or hydroxyapatite in the bone tissue regeneration process – in vitro and in vivo examinations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738921/
https://www.ncbi.nlm.nih.gov/pubmed/19742134
http://dx.doi.org/10.3390/ijms10073224
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