Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

BACKGROUND: Mitochondrial oxidative stress is a contributing factor in the etiology of numerous neuronal disorders. However, the precise mechanism(s) by which mitochondrial reactive oxygen species (ROS) modify cellular targets to induce the death of neurons remains unknown. The goal of this study wa...

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Detalles Bibliográficos
Autores principales: Cantu, David, Schaack, Jerome, Patel, Manisha
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738973/
https://www.ncbi.nlm.nih.gov/pubmed/19763183
http://dx.doi.org/10.1371/journal.pone.0007095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738973/
https://www.ncbi.nlm.nih.gov/pubmed/19763183
http://dx.doi.org/10.1371/journal.pone.0007095

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