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Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
BACKGROUND: Mitochondrial oxidative stress is a contributing factor in the etiology of numerous neuronal disorders. However, the precise mechanism(s) by which mitochondrial reactive oxygen species (ROS) modify cellular targets to induce the death of neurons remains unknown. The goal of this study wa...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738973/ https://www.ncbi.nlm.nih.gov/pubmed/19763183 http://dx.doi.org/10.1371/journal.pone.0007095 |