Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

MicroRNAs (miRNAs) posttranscriptionally regulate targeted messenger RNAs (mRNAs) by inducing cleavage or otherwise repressing their translation. We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivat...

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Detalles Bibliográficos
Autores principales: Stanhope, Stephen A., Sengupta, Srikumar, den Boon, Johan, Ahlquist, Paul, Newton, Michael A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739424/
https://www.ncbi.nlm.nih.gov/pubmed/19779550
http://dx.doi.org/10.1371/journal.pcbi.1000516

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