Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle. The resulting frame-shift reveals a premature stop codon that causes nonsense-mediated decay of the mutant messenger RNA, and the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fasquelle, Corinne, Sartelet, Arnaud, Li, Wanbo, Dive, Marc, Tamma, Nico, Michaux, Charles, Druet, Tom, Huijbers, Ivo J., Isacke, Clare M., Coppieters, Wouter, Georges, Michel, Charlier, Carole
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739430/
https://www.ncbi.nlm.nih.gov/pubmed/19779552
http://dx.doi.org/10.1371/journal.pgen.1000666

Ejemplares similares

Ejemplares similares