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Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens

Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood ox...

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Autores principales: Ye, Xianghai, Brown, Stewart R, Nones, Kátia, Coutinho, Luiz L, Dekkers, Jack CM, Lamont, Susan J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739435/
https://www.ncbi.nlm.nih.gov/pubmed/17212949
http://dx.doi.org/10.1186/1297-9686-39-1-73
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author Ye, Xianghai
Brown, Stewart R
Nones, Kátia
Coutinho, Luiz L
Dekkers, Jack CM
Lamont, Susan J
author_facet Ye, Xianghai
Brown, Stewart R
Nones, Kátia
Coutinho, Luiz L
Dekkers, Jack CM
Lamont, Susan J
author_sort Ye, Xianghai
collection PubMed
description Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
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spelling pubmed-27394352009-09-09 Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens Ye, Xianghai Brown, Stewart R Nones, Kátia Coutinho, Luiz L Dekkers, Jack CM Lamont, Susan J Genet Sel Evol Research Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance. BioMed Central 2007-01-11 /pmc/articles/PMC2739435/ /pubmed/17212949 http://dx.doi.org/10.1186/1297-9686-39-1-73 Text en Copyright © 2006 INRA, EDP Sciences
spellingShingle Research
Ye, Xianghai
Brown, Stewart R
Nones, Kátia
Coutinho, Luiz L
Dekkers, Jack CM
Lamont, Susan J
Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title_full Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title_fullStr Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title_full_unstemmed Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title_short Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
title_sort associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739435/
https://www.ncbi.nlm.nih.gov/pubmed/17212949
http://dx.doi.org/10.1186/1297-9686-39-1-73
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