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Integration of Evolutionary Features for the Identification of Functionally Important Residues in Major Facilitator Superfamily Transporters

The identification of functionally important residues is an important challenge for understanding the molecular mechanisms of proteins. Membrane protein transporters operate two-state allosteric conformational changes using functionally important cooperative residues that mediate long-range communic...

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Detalles Bibliográficos
Autores principales: Jeon, Jouhyun, Yang, Jae-Seong, Kim, Sanguk
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739438/
https://www.ncbi.nlm.nih.gov/pubmed/19798434
http://dx.doi.org/10.1371/journal.pcbi.1000522