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Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin

BACKGROUND: Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and atherosclerosis. Decreased HSPG may contribute to diabetic endothelial injury. Decre...

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Detalles Bibliográficos
Autores principales:	Han, Juying, Zhang, Fuming, Xie, Jin, Linhardt, Robert J, Hiebert, Linda M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739842/ https://www.ncbi.nlm.nih.gov/pubmed/19695080 http://dx.doi.org/10.1186/1475-2840-8-46

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