Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report

HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported. We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a m...

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Detalles Bibliográficos
Autores principales: Elghissassi, Ibrahim, Inrhaoun, Hanane, Vignot, Stephane, Mrabti, Hind, Errihani, Hassan
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740012/
https://www.ncbi.nlm.nih.gov/pubmed/19918269
http://dx.doi.org/10.4076/1757-1626-2-8099
Descripción
Sumario:HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported. We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a metastatic breast cancer to lymph nodes. Initially, the breast tumor HER-2 status was positive according to the same technique. We raise a hypothesis about technical interference and discuss the case in the framework of the existing literature.

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