Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report

HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported. We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a m...

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Autores principales: Elghissassi, Ibrahim, Inrhaoun, Hanane, Vignot, Stephane, Mrabti, Hind, Errihani, Hassan
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740012/
https://www.ncbi.nlm.nih.gov/pubmed/19918269
http://dx.doi.org/10.4076/1757-1626-2-8099
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author Elghissassi, Ibrahim
Inrhaoun, Hanane
Vignot, Stephane
Mrabti, Hind
Errihani, Hassan
author_facet Elghissassi, Ibrahim
Inrhaoun, Hanane
Vignot, Stephane
Mrabti, Hind
Errihani, Hassan
author_sort Elghissassi, Ibrahim
collection PubMed
description HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported. We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a metastatic breast cancer to lymph nodes. Initially, the breast tumor HER-2 status was positive according to the same technique. We raise a hypothesis about technical interference and discuss the case in the framework of the existing literature.
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spelling pubmed-27400122009-11-16 Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report Elghissassi, Ibrahim Inrhaoun, Hanane Vignot, Stephane Mrabti, Hind Errihani, Hassan Cases J Case report HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported. We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a metastatic breast cancer to lymph nodes. Initially, the breast tumor HER-2 status was positive according to the same technique. We raise a hypothesis about technical interference and discuss the case in the framework of the existing literature. Cases Network Ltd 2009-06-09 /pmc/articles/PMC2740012/ /pubmed/19918269 http://dx.doi.org/10.4076/1757-1626-2-8099 Text en © 2009 Elghissassi et al.; licensee Cases Network Ltd. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Elghissassi, Ibrahim
Inrhaoun, Hanane
Vignot, Stephane
Mrabti, Hind
Errihani, Hassan
Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title_full Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title_fullStr Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title_full_unstemmed Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title_short Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report
title_sort reduction in her-2 protein expression in a breast tumor her-2 positive after only one injection of trastuzumab: a case report
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740012/
https://www.ncbi.nlm.nih.gov/pubmed/19918269
http://dx.doi.org/10.4076/1757-1626-2-8099
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