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Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report

INTRODUCTION: Chemotherapy related encephalopathy is commonly reported with certain forms of chemotherapy but few reports note an association with low dose 5-Fluorouracil. CASE PRESENTATION: A 57-year-old Caucasian lady received her first cycle of Cisplatin and 5-Fluorouracil for palliative treatmen...

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Autores principales: Chue, Amy L, Fernando, Indrajit N, Hussain, Syed A, Yates, David A
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740264/
https://www.ncbi.nlm.nih.gov/pubmed/19830079
http://dx.doi.org/10.4076/1757-1626-2-8526
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author Chue, Amy L
Fernando, Indrajit N
Hussain, Syed A
Yates, David A
author_facet Chue, Amy L
Fernando, Indrajit N
Hussain, Syed A
Yates, David A
author_sort Chue, Amy L
collection PubMed
description INTRODUCTION: Chemotherapy related encephalopathy is commonly reported with certain forms of chemotherapy but few reports note an association with low dose 5-Fluorouracil. CASE PRESENTATION: A 57-year-old Caucasian lady received her first cycle of Cisplatin and 5-Fluorouracil for palliative treatment of cervical carcinoma, and presented several days later with signs of encephalopathy. Several causes were eliminated, and encephalopathy related to 5-Fluorouracil was thought to be the most likely cause. Magnetic Resonance Imaging of the head revealed changes related to the chemotherapy received. Symptoms resolved completely within three days of presentation. CONCLUSION: Encephalopathy from low dose 5-Fluorouracil is not well documented in the literature. Fluid rehydration and supportive treatment is required. Signs and symptoms resolved completely with no residual effects on follow up.
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spelling pubmed-27402642009-10-14 Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report Chue, Amy L Fernando, Indrajit N Hussain, Syed A Yates, David A Cases J Case report INTRODUCTION: Chemotherapy related encephalopathy is commonly reported with certain forms of chemotherapy but few reports note an association with low dose 5-Fluorouracil. CASE PRESENTATION: A 57-year-old Caucasian lady received her first cycle of Cisplatin and 5-Fluorouracil for palliative treatment of cervical carcinoma, and presented several days later with signs of encephalopathy. Several causes were eliminated, and encephalopathy related to 5-Fluorouracil was thought to be the most likely cause. Magnetic Resonance Imaging of the head revealed changes related to the chemotherapy received. Symptoms resolved completely within three days of presentation. CONCLUSION: Encephalopathy from low dose 5-Fluorouracil is not well documented in the literature. Fluid rehydration and supportive treatment is required. Signs and symptoms resolved completely with no residual effects on follow up. Cases Network Ltd 2009-07-30 /pmc/articles/PMC2740264/ /pubmed/19830079 http://dx.doi.org/10.4076/1757-1626-2-8526 Text en © 2009 Chue et al.; licensee Cases Network Ltd. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Chue, Amy L
Fernando, Indrajit N
Hussain, Syed A
Yates, David A
Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title_full Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title_fullStr Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title_full_unstemmed Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title_short Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
title_sort chemotherapy related encephalopathy in a patient with stage iv cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740264/
https://www.ncbi.nlm.nih.gov/pubmed/19830079
http://dx.doi.org/10.4076/1757-1626-2-8526
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AT hussainsyeda chemotherapyrelatedencephalopathyinapatientwithstageivcervicalcarcinomatreatedwithcisplatinand5fluorouracilacasereport
AT yatesdavida chemotherapyrelatedencephalopathyinapatientwithstageivcervicalcarcinomatreatedwithcisplatinand5fluorouracilacasereport