Volumetric and Anatomic MRI for Hypoxic-Ischemic Encephalopathy: Relationship to Hypothermia Therapy and Neurosensory Impairments

OBJECTIVE: To relate volumetric MRI findings to hypothermia therapy and neurosensory impairments. STUDY DESIGN: Newborns ≥ 36 weeks’ gestation with hypoxic-ischemic encephalopathy who participated in the NICHD hypothermia randomized trial at our center were eligible. We determined the relationship between hypothermia treatment and usual care (control) to absolute and relative cerebral tissue volumes. Further, we correlated brain volumes with death or neurosensory impairments at 18 to 22 months. RESULTS: Both treatment groups were comparable before randomization. Total brain tissue volumes did not differ in relation to treatment assignment. However, relative volumes of subcortical white matter were significantly larger in hypothermia-treated than control infants. Furthermore, relative total brain volumes correlated significantly with death or neurosensory impairments. Relative volumes of the cortical gray and subcortical white matter also correlated significantly with Bayley Scales psychomotor development index. CONCLUSION: Selected volumetric MRI findings correlated with hypothermia therapy and neurosensory impairments. Larger studies utilizing MRI brain volumes as a secondary outcome measure are needed.