Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors

Gonadotropin-releasing hormone (GnRH) acts via seven transmembrane receptors to stimulate gonadotropin secretion. Sustained stimulation desensitizes GnRH receptor (GnRHR)-mediated gonadotropin secretion, and this underlies agonist use in hormone-dependent cancers. Since type I mammalian GnRHR do not...

Descripción completa

Detalles Bibliográficos
Autores principales: Finch, Ann R., Caunt, Christopher J., Armstrong, Stephen P., McArdle, Craig A.
Formato: Texto
Lenguaje:English
Publicado: American Physiological Society 2009
Materias:
Receptors and Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740399/
https://www.ncbi.nlm.nih.gov/pubmed/19587220
http://dx.doi.org/10.1152/ajpcell.00166.2009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740399/
https://www.ncbi.nlm.nih.gov/pubmed/19587220
http://dx.doi.org/10.1152/ajpcell.00166.2009

Ejemplares similares