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Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle

Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413). K38Q-MCT1 and K38R-MCT1 were inactive when expressed at the plasma membrane of Xenopus laevis oocytes, whereas K45R/K282R/K413R-MCT1 and K45Q/K282Q/K413Q-MCT1 were active. The former exhibi...

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Detalles Bibliográficos
Autores principales:	Wilson, Marieangela C., Meredith, David, Bunnun, Chotirote, Sessions, Richard B., Halestrap, Andrew P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Membrane Transport, Structure, Function, and Biogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740427/ https://www.ncbi.nlm.nih.gov/pubmed/19473976 http://dx.doi.org/10.1074/jbc.M109.014217

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