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Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction

Matrix metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2) are expressed in both sporadic and familial adenomatous colonic polyps and tumours and have been independently shown to play causal roles in intestinal tumour formation in mouse models of colon cancer. The apparent roles of these enzymes...

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Detalles Bibliográficos
Autores principales:	Wagenaar-Miller, R A, Hanley, G, Shattuck-Brandt, R, DuBois, R N, Bell, R L, Matrisian, L M, Morgan, D W
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741031/ https://www.ncbi.nlm.nih.gov/pubmed/12778076 http://dx.doi.org/10.1038/sj.bjc.6600867

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