Cargando…

Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts

New blood vessel formation within tumours is a critical feature for tumour growth. A major limitation in understanding this complex process has been the inability to visualise and analyse vessel formation. Here, we report on the development of a whole-tissue mount technique that allows visualisation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gerber, S A, Moran, J P, Frelinger, J G, Frelinger, J A, Fenton, B M, Lord, E M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741041/ https://www.ncbi.nlm.nih.gov/pubmed/12778077 http://dx.doi.org/10.1038/sj.bjc.6600907

Ejemplares similares

Alteration of tumour response to radiation by interleukin-2 gene transfer
por: Lee, J, et al.
Publicado: (2000)

A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels
por: Palumbo, A, et al.
Publicado: (2011)

Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12
por: Barker, S E, et al.
Publicado: (2007)

Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12
por: Siapati, K E, et al.
Publicado: (2003)

IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein
por: Joshi, B H, et al.
Publicado: (2002)

Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice
por: Bing, C, et al.
Publicado: (2006)

Flagellin Treatment Prevents Increased Susceptibility to Systemic Bacterial Infection after Injury by Inhibiting Anti-Inflammatory IL-10+ IL-12- Neutrophil Polarization
por: Neely, Crystal J., et al.
Publicado: (2014)

Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis
por: Fenton, B M, et al.
Publicado: (2002)

The role of tumour-derived iNOS in tumour progression and angiogenesis
por: Kostourou, V, et al.
Publicado: (2011)

Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia
por: Blair, Thomas A., et al.
Publicado: (2018)

Oestradiol enhances tumour regression induced by B7-1/IL-2 adenoviral gene transfer in a murine model of breast cancer
por: Dabrosin, C, et al.
Publicado: (2003)

Plexin-B2 and Plexin-D1 in Dendritic Cells: Expression and IL-12/IL-23p40 Production
por: Holl, Eda K., et al.
Publicado: (2012)

A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells
por: Wang, M, et al.
Publicado: (2003)

Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming
por: Merrick, A, et al.
Publicado: (2005)

Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
por: Purohit, A, et al.
Publicado: (2003)

Whole-mount immunofluorescence staining of blood and lymphatic vessels in murine small intestine
por: Paavonsalo, Satu, et al.
Publicado: (2023)

Induction of tumour-specific CD8(+) cytotoxic T lymphocytes by tumour lysate-pulsed autologous dendritic cells in patients with uterine serous papillary cancer
por: Santin, A D, et al.
Publicado: (2002)

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)
por: Duverger, V, et al.
Publicado: (2004)

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. II. H-2 D region control of H-7.1-specific stimulator function in mixed lymphocyte culture and susceptibility to lysis by H-7.1- specific cytotoxic cells
por: Wettstein, PJ, et al.
Publicado: (1977)

Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours
por: Beloueche-Babari, M, et al.
Publicado: (2015)

Invasion and MMP expression profile in desmoid tumours
por: Denys, H, et al.
Publicado: (2004)

Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1
por: Tian, S, et al.
Publicado: (2002)

Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection
por: Powell, Daniel A., et al.
Publicado: (2017)

Resistance to fatal central nervous system disease by mouse hepatitis virus, strain JHM: I. Genetic analysis
por: Stohlman, Stephen A., et al.
Publicado: (1978)

Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model
por: Hermes, M, et al.
Publicado: (2008)

Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin
por: Piccirillo, S G M, et al.
Publicado: (2012)

Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours
por: Seront, E, et al.
Publicado: (2013)

False-negative MRI biomarkers of tumour response to targeted cancer therapeutics
por: Boult, J K R, et al.
Publicado: (2012)

Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging
por: Robinson, S P, et al.
Publicado: (2003)

The role of superoxide anions in the development of distant tumour recurrence
por: ten Kate, M, et al.
Publicado: (2006)

Malignant germ cell tumours of the testis express interferon-γ, but are resistant to endogenous interferon-γ
por: Schweyer, S, et al.
Publicado: (2003)

Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas
por: Separovic, D, et al.
Publicado: (2009)

Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells
por: Scheffer, G L, et al.
Publicado: (2002)

Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis
por: Kostourou, V, et al.
Publicado: (2002)

Fractionated (131)I anti-CEA radioimmunotherapy: effects on xenograft tumour growth and haematological toxicity in mice
por: Violet, J A, et al.
Publicado: (2008)

Using macrophage activation to augment immunotherapy of established tumours
por: Fridlender, Z G, et al.
Publicado: (2013)

Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
por: Ioannou, N, et al.
Publicado: (2011)

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models
por: Jarzabek, M A, et al.
Publicado: (2014)

Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction
por: Lickliter, J D, et al.
Publicado: (2007)

Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo
por: Tunstall, R G, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_f44eb8r5a865cjuen7j69ti9vb