Cargando…

Immunotherapy with concurrent subcutaneous GM-CSF, low-dose IL-2 and IFN-α in patients with progressive metastatic renal cell carcinoma

The purpose of the study was to determine toxicity, efficacy and immunologic effects of concurrent subcutaneous injections of low-dose interleukin-2 (LD-IL-2), granulocyte–monocyte colony-stimulating factor (GM-CSF) and interferon-α 2b (IFNα) in progressive metastatic renal cell carcinoma. In a mult...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verra, N, Jansen, R, Groenewegen, G, Mallo, H, Kersten, M J, Bex, A, Vyth-Dreese, F A, Sein, J, van de Kasteele, W, Nooijen, W J, de Waal, M, Horenblas, S, de Gast, G C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741048/ https://www.ncbi.nlm.nih.gov/pubmed/12778059 http://dx.doi.org/10.1038/sj.bjc.6600915

Ejemplares similares

Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFNα in patients with metastatic melanoma
por: de Gast, G C, et al.
Publicado: (2003)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

Targeting the Endothelin Axis with Atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma
por: Groenewegen, G, et al.
Publicado: (2012)

IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ
por: Foucher, Etienne D., et al.
Publicado: (2013)

SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration
por: Zhang, Xuejie, et al.
Publicado: (2020)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Functional characterization of GM-CSF induced monocyte subsets
por: Däbritz, J, et al.
Publicado: (2008)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

A phase I study of prolonged continuous infusion of low dose recombinant interleukin-2 in melanoma and renal cell cancer. Part II: Immunological aspects.
por: Vlasveld, L. T., et al.
Publicado: (1993)

Correction: IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ
por: Foucher, Etienne D., et al.
Publicado: (2014)

Neutrophil GM‐CSF receptor dynamics in acute lung injury
por: De Alessandris, Silvia, et al.
Publicado: (2019)

G-CSF and GM-CSF Modify Neutrophil Functions at Concentrations found in Cystic Fibrosis
por: Castellani, Stefano, et al.
Publicado: (2019)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

Cytokine/Chemokine Release Patterns and Transcriptomic Profiles of LPS/IFNγ-Activated Human Macrophages Differentiated with Heat-Killed Mycobacterium obuense, M-CSF, or GM-CSF
por: Bazzi, Samer, et al.
Publicado: (2021)

Retrovirus mediated transfer and expression of GM-CSF in haematopoietic cells.
por: Keith, W. N., et al.
Publicado: (1990)

Cytokines, GM-CSF and IFNγ administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin
por: Apte, Sachin M, et al.
Publicado: (2006)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Role of GM-CSF in lung balance and disease
por: Chen, Yingzi, et al.
Publicado: (2023)

Stimulating severe COVID-19: the potential role of GM-CSF antagonism
por: Leavis, Helen L, et al.
Publicado: (2022)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
por: Enzler, Thomas, et al.
Publicado: (2003)

rhGM-CSF ameliorates neutropenia in patients with malignant glioma treated with BCNU.
por: Rampling, R., et al.
Publicado: (1994)

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
por: Van Dis, Erik, et al.
Publicado: (2022)

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies
por: Bonaventura, Aldo, et al.
Publicado: (2020)

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment
por: Martinez Sanz, Paula, et al.
Publicado: (2021)

Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
por: Cook, Andrew D, et al.
Publicado: (2001)

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
por: Al-Mossawi, M. H., et al.
Publicado: (2017)

Delivery of GM-CSF to Protect against Influenza Pneumonia
por: Subramaniam, Renuka, et al.
Publicado: (2015)

GM-CSF as a therapeutic target in autoimmune diseases
por: Shiomi, Aoi, et al.
Publicado: (2016)

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update
por: Lotfi, Noushin, et al.
Publicado: (2019)

GM-CSF: A Promising Target in Inflammation and Autoimmunity
por: Lee, Kevin M C, et al.
Publicado: (2020)

Increased in vitro Cell Proliferation by Chitosan/pGM-CSF Complexes
por: Şalva, E., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8g6c2biaqppho27j78s2653lu6