Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting...

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Detalles Bibliográficos
Autores principales: Tonetti, D A, Morrow, M, Kidwai, N, Gupta, A, Badve, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741052/
https://www.ncbi.nlm.nih.gov/pubmed/12778068
http://dx.doi.org/10.1038/sj.bjc.6600923
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author Tonetti, D A
Morrow, M
Kidwai, N
Gupta, A
Badve, S
author_facet Tonetti, D A
Morrow, M
Kidwai, N
Gupta, A
Badve, S
author_sort Tonetti, D A
collection PubMed
description We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.
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spelling pubmed-27410522009-09-10 Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure Tonetti, D A Morrow, M Kidwai, N Gupta, A Badve, S Br J Cancer Molecular and Cellular Pathology We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure. Nature Publishing Group 2003-05-06 2003-04-29 /pmc/articles/PMC2741052/ /pubmed/12778068 http://dx.doi.org/10.1038/sj.bjc.6600923 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Tonetti, D A
Morrow, M
Kidwai, N
Gupta, A
Badve, S
Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title_full Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title_fullStr Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title_full_unstemmed Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title_short Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
title_sort elevated protein kinase c alpha expression may be predictive of tamoxifen treatment failure
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741052/
https://www.ncbi.nlm.nih.gov/pubmed/12778068
http://dx.doi.org/10.1038/sj.bjc.6600923
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AT kidwain elevatedproteinkinasecalphaexpressionmaybepredictiveoftamoxifentreatmentfailure
AT guptaa elevatedproteinkinasecalphaexpressionmaybepredictiveoftamoxifentreatmentfailure
AT badves elevatedproteinkinasecalphaexpressionmaybepredictiveoftamoxifentreatmentfailure

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