Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may...

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Autores principales: Hone, P, Edwards, A, Halls, J, Cox, R, Lloyd, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741117/
https://www.ncbi.nlm.nih.gov/pubmed/12799640
http://dx.doi.org/10.1038/sj.bjc.6601010
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author Hone, P
Edwards, A
Halls, J
Cox, R
Lloyd, D
author_facet Hone, P
Edwards, A
Halls, J
Cox, R
Lloyd, D
author_sort Hone, P
collection PubMed
description Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10–15% (2SE).
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spelling pubmed-27411172009-09-10 Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia Hone, P Edwards, A Halls, J Cox, R Lloyd, D Br J Cancer Experimental Therapeutics Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10–15% (2SE). Nature Publishing Group 2003-06-16 2003-06-10 /pmc/articles/PMC2741117/ /pubmed/12799640 http://dx.doi.org/10.1038/sj.bjc.6601010 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Hone, P
Edwards, A
Halls, J
Cox, R
Lloyd, D
Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title_full Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title_fullStr Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title_full_unstemmed Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title_short Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia
title_sort possible associations between elf electromagnetic fields, dna damage response processes and childhood leukaemia
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741117/
https://www.ncbi.nlm.nih.gov/pubmed/12799640
http://dx.doi.org/10.1038/sj.bjc.6601010
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