Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity

Paclitaxel and oxaliplatin are promising drugs for combination trials but both induce peripheral neurotoxicity. To investigate this toxicity, 10-week-old female Wistar rats were given single intraperitoneal doses of paclitaxel and oxaliplatin, alone or in combination. Neurotoxicity was assessed by L...

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Detalles Bibliográficos
Autores principales: Jamieson, S M F, Liu, J, Hsu, T, Baguley, B C, McKeage, M J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741119/
https://www.ncbi.nlm.nih.gov/pubmed/12799641
http://dx.doi.org/10.1038/sj.bjc.6601012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741119/
https://www.ncbi.nlm.nih.gov/pubmed/12799641
http://dx.doi.org/10.1038/sj.bjc.6601012

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