Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?

We analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neuroblastoma and found that patients whose grafts contained detectable neuroblastoma cells had a significantly higher probability of survival than did patients with no detectable tumou...

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Autores principales: Handgretinger, R, Leung, W, Ihm, K, Lang, P, Klingebiel, T, Niethammer, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741120/
https://www.ncbi.nlm.nih.gov/pubmed/12799629
http://dx.doi.org/10.1038/sj.bjc.6601014
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author Handgretinger, R
Leung, W
Ihm, K
Lang, P
Klingebiel, T
Niethammer, D
author_facet Handgretinger, R
Leung, W
Ihm, K
Lang, P
Klingebiel, T
Niethammer, D
author_sort Handgretinger, R
collection PubMed
description We analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neuroblastoma and found that patients whose grafts contained detectable neuroblastoma cells had a significantly higher probability of survival than did patients with no detectable tumour cells. Estimated contamination of the graft by more than 2000 tumour cells was associated with a significantly higher probability of survival than contamination with fewer tumour cells. We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation.
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spelling pubmed-27411202009-09-10 Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news? Handgretinger, R Leung, W Ihm, K Lang, P Klingebiel, T Niethammer, D Br J Cancer Molecular and Cellular Pathology We analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neuroblastoma and found that patients whose grafts contained detectable neuroblastoma cells had a significantly higher probability of survival than did patients with no detectable tumour cells. Estimated contamination of the graft by more than 2000 tumour cells was associated with a significantly higher probability of survival than contamination with fewer tumour cells. We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation. Nature Publishing Group 2003-06-16 2003-06-10 /pmc/articles/PMC2741120/ /pubmed/12799629 http://dx.doi.org/10.1038/sj.bjc.6601014 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Handgretinger, R
Leung, W
Ihm, K
Lang, P
Klingebiel, T
Niethammer, D
Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title_full Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title_fullStr Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title_full_unstemmed Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title_short Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
title_sort tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741120/
https://www.ncbi.nlm.nih.gov/pubmed/12799629
http://dx.doi.org/10.1038/sj.bjc.6601014
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