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Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects

The ventral striatum/nucleus accumbens (NAcc) has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the NAcc may significantly...

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Autores principales: Heinze, Hans-Jochen, Heldmann, Marcus, Voges, Jürgen, Hinrichs, Hermann, Marco-Pallares, Josep, Hopf, Jens-Max, Müller, Ulf J., Galazky, Imke, Sturm, Volker, Bogerts, Bernard, Münte, Thomas F.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741292/
https://www.ncbi.nlm.nih.gov/pubmed/19750197
http://dx.doi.org/10.3389/neuro.09.022.2009
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author Heinze, Hans-Jochen
Heldmann, Marcus
Voges, Jürgen
Hinrichs, Hermann
Marco-Pallares, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
author_facet Heinze, Hans-Jochen
Heldmann, Marcus
Voges, Jürgen
Hinrichs, Hermann
Marco-Pallares, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
author_sort Heinze, Hans-Jochen
collection PubMed
description The ventral striatum/nucleus accumbens (NAcc) has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the NAcc may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the NAcc bilaterally. All three had been alcohol-dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug-related cues. LFPs in the action monitoring task provided further evidence for a role of the NAcc in goal-directed behaviors. Importantly, alcohol-related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the NAcc and is highly automatic.
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spelling pubmed-27412922009-09-10 Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects Heinze, Hans-Jochen Heldmann, Marcus Voges, Jürgen Hinrichs, Hermann Marco-Pallares, Josep Hopf, Jens-Max Müller, Ulf J. Galazky, Imke Sturm, Volker Bogerts, Bernard Münte, Thomas F. Front Hum Neurosci Neuroscience The ventral striatum/nucleus accumbens (NAcc) has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the NAcc may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the NAcc bilaterally. All three had been alcohol-dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug-related cues. LFPs in the action monitoring task provided further evidence for a role of the NAcc in goal-directed behaviors. Importantly, alcohol-related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the NAcc and is highly automatic. Frontiers Research Foundation 2009-09-02 /pmc/articles/PMC2741292/ /pubmed/19750197 http://dx.doi.org/10.3389/neuro.09.022.2009 Text en Copyright © 2009 Heinze, Heldmann, Voges, Hinrichs, Marco-Pallares, Hopf, Müller, Galazky, Sturm, Bogerts and Münte. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Heinze, Hans-Jochen
Heldmann, Marcus
Voges, Jürgen
Hinrichs, Hermann
Marco-Pallares, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title_full Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title_fullStr Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title_full_unstemmed Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title_short Counteracting Incentive Sensitization in Severe Alcohol Dependence using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects
title_sort counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741292/
https://www.ncbi.nlm.nih.gov/pubmed/19750197
http://dx.doi.org/10.3389/neuro.09.022.2009
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