FRAGILE X MENTAL RETARDATION PROTEIN REPLACEMENT RESTORES HIPPOCAMPAL SYNAPTIC FUNCTION IN A MOUSE MODEL OF FRAGILE X SYNDROME

Fragile X Syndrome (FXS) is caused by a mutation that silences the Fragile X Mental Retardation gene (FMR1) which encodes the Fragile X Mental Retardation Protein (FMRP). To determine if FMRP replacement can rescue phenotypic deficits in an fmr1 knockout (KO) mouse model of FXS, we constructed an Ad...

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Detalles Bibliográficos
Autores principales: Zeier, Zane, Kumar, Ashok, Bodhinathan, Karthik, Feller, Joyce A., Foster, Thomas C., Bloom, David C.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741536/
https://www.ncbi.nlm.nih.gov/pubmed/19571888
http://dx.doi.org/10.1038/gt.2009.83

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