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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

The Nek family of serine/threonine kinases regulates centrosome and cilia function; in addition, several of its members are potential targets for drug discovery. Nek2 is dimeric, is cell cycle regulated and functions in the separation of centrosomes at G2/M. Here, we report the crystal structures of...

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Detalles Bibliográficos
Autores principales:	Westwood, Isaac, Cheary, Donna-Marie, Baxter, Joanne E., Richards, Mark W., van Montfort, Rob L.M., Fry, Andrew M., Bayliss, Richard
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741569/ https://www.ncbi.nlm.nih.gov/pubmed/19124027 http://dx.doi.org/10.1016/j.jmb.2008.12.033

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