Out of the Box Binding Determines Specificity of SH2 Domain Interaction

SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.

Detalles Bibliográficos
Autores principales: Müller, Susanne, Knapp, Stefan
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741584/
https://www.ncbi.nlm.nih.gov/pubmed/19679083
http://dx.doi.org/10.1016/j.str.2009.07.002
_version_ 1782171804415033344
author Müller, Susanne
Knapp, Stefan
author_facet Müller, Susanne
Knapp, Stefan
author_sort Müller, Susanne
collection PubMed
description SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
format Text
id pubmed-2741584
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-27415842009-09-17 Out of the Box Binding Determines Specificity of SH2 Domain Interaction Müller, Susanne Knapp, Stefan Structure Preview SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket. Cell Press 2009-08-12 /pmc/articles/PMC2741584/ /pubmed/19679083 http://dx.doi.org/10.1016/j.str.2009.07.002 Text en © 2009 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Preview
Müller, Susanne
Knapp, Stefan
Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title_full Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title_fullStr Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title_full_unstemmed Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title_short Out of the Box Binding Determines Specificity of SH2 Domain Interaction
title_sort out of the box binding determines specificity of sh2 domain interaction
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741584/
https://www.ncbi.nlm.nih.gov/pubmed/19679083
http://dx.doi.org/10.1016/j.str.2009.07.002
work_keys_str_mv AT mullersusanne outoftheboxbindingdeterminesspecificityofsh2domaininteraction
AT knappstefan outoftheboxbindingdeterminesspecificityofsh2domaininteraction

Ejemplares similares