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Out of the Box Binding Determines Specificity of SH2 Domain Interaction
SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741584/ https://www.ncbi.nlm.nih.gov/pubmed/19679083 http://dx.doi.org/10.1016/j.str.2009.07.002 |