Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase

Predicting mutations that enhance protein–protein affinity remains a challenging task, especially for high-affinity complexes. To test our capability to improve the affinity of such complexes, we studied interaction of acetylcholinesterase with the snake toxin, fasciculin. Using the program ORBIT, w...

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Detalles Bibliográficos
Autores principales: Sharabi, Oz, Peleg, Yoav, Mashiach, Efrat, Vardy, Eyal, Ashani, Yacov, Silman, Israel, Sussman, Joel L., Shifman, Julia M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Original articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742391/
https://www.ncbi.nlm.nih.gov/pubmed/19643977
http://dx.doi.org/10.1093/protein/gzp045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742391/
https://www.ncbi.nlm.nih.gov/pubmed/19643977
http://dx.doi.org/10.1093/protein/gzp045

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