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Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase
Predicting mutations that enhance protein–protein affinity remains a challenging task, especially for high-affinity complexes. To test our capability to improve the affinity of such complexes, we studied interaction of acetylcholinesterase with the snake toxin, fasciculin. Using the program ORBIT, w...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742391/ https://www.ncbi.nlm.nih.gov/pubmed/19643977 http://dx.doi.org/10.1093/protein/gzp045 |