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Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse

Following a screen for neuromuscular mouse mutants, we identified ostes, a novel N-ethyl N-nitrosourea-induced mouse mutant with muscle atrophy. Genetic and biochemical evidence shows that upregulation of the novel, uncharacterized transient receptor potential polycystic (TRPP) channel PKD1L2 (polyc...

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Detalles Bibliográficos
Autores principales:	Mackenzie, Francesca E., Romero, Rosario, Williams, Debbie, Gillingwater, Thomas, Hilton, Helen, Dick, Jim, Riddoch-Contreras, Joanna, Wong, Frances, Ireson, Lisa, Powles-Glover, Nicola, Riley, Genna, Underhill, Peter, Hough, Tertius, Arkell, Ruth, Greensmith, Linda, Ribchester, Richard R., Blanco, Gonzalo
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742400/ https://www.ncbi.nlm.nih.gov/pubmed/19578180 http://dx.doi.org/10.1093/hmg/ddp304

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