Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus

Therapeutic retroviral vector integration near the oncogene LMO2 is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the LMO2 locus. We identified a high incidence region (HIR) of vector...

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Detalles Bibliográficos
Autores principales: Yamada, Koichiro, Tsukahara, Tomonori, Yoshino, Kazuhisa, Kojima, Katsuhiko, Agawa, Hideyuki, Yamashita, Yuki, Amano, Yuji, Hatta, Mariko, Matsuzaki, Yasunori, Kurotori, Naoki, Wakui, Keiko, Fukushima, Yoshimitsu, Osada, Ryosuke, Shiozawa, Tanri, Sakashita, Kazuo, Koike, Kenichi, Kumaki, Satoru, Tanaka, Nobuyuki, Takeshita, Toshikazu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742512/
https://www.ncbi.nlm.nih.gov/pubmed/19725963
http://dx.doi.org/10.1186/1742-4690-6-79

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