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Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2,...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Japan Society of Histochemistry and Cytochemistry
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742723/ https://www.ncbi.nlm.nih.gov/pubmed/19759870 http://dx.doi.org/10.1267/ahc.09004 |
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author | Osamura, Robert Y. Egashira, Noboru Kajiya, Hanako Takei, Mao Tobita, Maya Miyakoshi, Takashi Inomoto, Chie Takekoshi, Susumu Teramoto, Akira |
author_facet | Osamura, Robert Y. Egashira, Noboru Kajiya, Hanako Takei, Mao Tobita, Maya Miyakoshi, Takashi Inomoto, Chie Takekoshi, Susumu Teramoto, Akira |
author_sort | Osamura, Robert Y. |
collection | PubMed |
description | Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed. |
format | Text |
id | pubmed-2742723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Japan Society of Histochemistry and Cytochemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-27427232009-09-16 Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution Osamura, Robert Y. Egashira, Noboru Kajiya, Hanako Takei, Mao Tobita, Maya Miyakoshi, Takashi Inomoto, Chie Takekoshi, Susumu Teramoto, Akira Acta Histochem Cytochem Regular Article Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed. Japan Society of Histochemistry and Cytochemistry 2009-08-29 2009-08-11 /pmc/articles/PMC2742723/ /pubmed/19759870 http://dx.doi.org/10.1267/ahc.09004 Text en © 2009 The Japan Society of Histochemistry and Cytochemistry This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Article Osamura, Robert Y. Egashira, Noboru Kajiya, Hanako Takei, Mao Tobita, Maya Miyakoshi, Takashi Inomoto, Chie Takekoshi, Susumu Teramoto, Akira Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title | Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title_full | Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title_fullStr | Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title_full_unstemmed | Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title_short | Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution |
title_sort | pathology, pathogenesis and therapy of growth hormone (gh)-producing pituitary adenomas: technical advances in histochemistry and their contribution |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742723/ https://www.ncbi.nlm.nih.gov/pubmed/19759870 http://dx.doi.org/10.1267/ahc.09004 |
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