Cargando…

Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution

Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2,...

Descripción completa

Detalles Bibliográficos
Autores principales: Osamura, Robert Y., Egashira, Noboru, Kajiya, Hanako, Takei, Mao, Tobita, Maya, Miyakoshi, Takashi, Inomoto, Chie, Takekoshi, Susumu, Teramoto, Akira
Formato: Texto
Lenguaje:English
Publicado: Japan Society of Histochemistry and Cytochemistry 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742723/
https://www.ncbi.nlm.nih.gov/pubmed/19759870
http://dx.doi.org/10.1267/ahc.09004
_version_ 1782171843189276672
author Osamura, Robert Y.
Egashira, Noboru
Kajiya, Hanako
Takei, Mao
Tobita, Maya
Miyakoshi, Takashi
Inomoto, Chie
Takekoshi, Susumu
Teramoto, Akira
author_facet Osamura, Robert Y.
Egashira, Noboru
Kajiya, Hanako
Takei, Mao
Tobita, Maya
Miyakoshi, Takashi
Inomoto, Chie
Takekoshi, Susumu
Teramoto, Akira
author_sort Osamura, Robert Y.
collection PubMed
description Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed.
format Text
id pubmed-2742723
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Japan Society of Histochemistry and Cytochemistry
record_format MEDLINE/PubMed
spelling pubmed-27427232009-09-16 Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution Osamura, Robert Y. Egashira, Noboru Kajiya, Hanako Takei, Mao Tobita, Maya Miyakoshi, Takashi Inomoto, Chie Takekoshi, Susumu Teramoto, Akira Acta Histochem Cytochem Regular Article Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed. Japan Society of Histochemistry and Cytochemistry 2009-08-29 2009-08-11 /pmc/articles/PMC2742723/ /pubmed/19759870 http://dx.doi.org/10.1267/ahc.09004 Text en © 2009 The Japan Society of Histochemistry and Cytochemistry This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Article
Osamura, Robert Y.
Egashira, Noboru
Kajiya, Hanako
Takei, Mao
Tobita, Maya
Miyakoshi, Takashi
Inomoto, Chie
Takekoshi, Susumu
Teramoto, Akira
Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title_full Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title_fullStr Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title_full_unstemmed Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title_short Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
title_sort pathology, pathogenesis and therapy of growth hormone (gh)-producing pituitary adenomas: technical advances in histochemistry and their contribution
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742723/
https://www.ncbi.nlm.nih.gov/pubmed/19759870
http://dx.doi.org/10.1267/ahc.09004
work_keys_str_mv AT osamuraroberty pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT egashiranoboru pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT kajiyahanako pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT takeimao pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT tobitamaya pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT miyakoshitakashi pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT inomotochie pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT takekoshisusumu pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution
AT teramotoakira pathologypathogenesisandtherapyofgrowthhormoneghproducingpituitaryadenomastechnicaladvancesinhistochemistryandtheircontribution